X Chromosome Inactivation: When Dosage Counts
نویسندگان
چکیده
How do mammals count their X chromosomes and keep only one X active per cell? In this issue, Jonkers et al. (2009) show that Rnf12/RLIM, encoded by the X-linked gene Rnf12, induces X chromosome inactivation only when present above a certain threshold, a condition fulfilled when at least two Xs are active.
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عنوان ژورنال:
- Cell
دوره 139 شماره
صفحات -
تاریخ انتشار 2009